Association of PDGFRB, VEGFR2, and TGFB1 Gene Polymorphisms with Nintedanib Efficacy and Adverse Effects in Patients with Progressive Pulmonary Fibrosis.

doi:10.3390/ijms27177546

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Article

Association of PDGFRB, VEGFR2, and TGFB1 Gene Polymorphisms with Nintedanib Efficacy and Adverse Effects in Patients with Progressive Pulmonary Fibrosis.

International journal of molecular sciences - 23 Aug 2026

Djurdjevic Natasa, Pjevic Marija Dusanović, Stjepanovic Mihailo, Colic Nikola, Dimic-Janjic Sanja, Jankovic Jelena, Maric Nikola, Zecevic Andrej, Terzic Milica, Golubovic Aleksa, Milivojevic Ivan, Omcikus Maja, Ilic Branislav, Lukic Katarina, Mijatovic Snjezana, Grk Milka

Abstract excerpt

Progressive pulmonary fibrosis (PPF) comprises interstitial lung diseases characterized by progressive fibrosis and lung function decline. Nintedanib slows disease progression by inhibiting FGFR, VEGFR, and PDGFR signaling, but treatment response varies among patients. We investigated whether VEGFR2, PDGFRB, and TGFB1 gene variants are associated with nintedanib treatment outcomes, including changes in pulmonary...

Read the complete abstract on PubMed

Topics

Humans
Transforming Growth Factor beta1
Female
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Vascular Endothelial Growth Factor Receptor-2

Polymorphism, Single Nucleotide

Indoles

Middle Aged

Aged

Receptor, Platelet-Derived Growth Factor beta

Pulmonary Fibrosis

Disease Progression

Treatment Outcome

Genotype

Prospective Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 42737450
DOI: 10.3390/ijms27177546
PMCID: PMC13565948

Genes

PDGFRB
TGFB1

Provenance

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