Increased NETosis in Patients With Heart Failure Is Associated With Macrophage Activation Towards a Proinflammatory Phenotype.

doi:10.1111/jcmm.71306

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Article

Increased NETosis in Patients With Heart Failure Is Associated With Macrophage Activation Towards a Proinflammatory Phenotype.

Journal of cellular and molecular medicine - 1 Sept 2026

Kostin Sawa, Cabrera-Fuentes Hector A, Richter Manfred, Krizanic Florian, Ritter Oliver, Boisvert William A, Preissner Klaus T, Kelesidis Theodoros, Siasos Gerasimos, Pagonas Nikolaos

Abstract excerpt

In this study, we tested the hypothesis that there is an interaction between neutrophils (N) undergoing NETosis and the activation of macrophages (Mf) in the myocardium of patients with heart failure (HF). Ventricular biopsies were examined from patients with HF due to dilated (DCM, n = 7), ischemic (ICM, n = 7), or inflammatory (InfCM, n = 7) cardiomyopathy, as well as from 5 control patients. Quantification of...

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Topics

Humans
Heart Failure
Female
Macrophage Activation
Male
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Macrophages

Neutrophils

Phenotype

Antigens, CD

Extracellular Traps

Inflammation

Peroxidase

Aged

Receptors, Cell Surface

GPI-Linked Proteins

Myocardium

Cell Adhesion Molecules

Source

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Identifiers

PMID: 42725813
DOI: 10.1111/jcmm.71306
PMCID: PMC13564250

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