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Article

Hyperdopaminergic States Bias Explorations-Exploitation Trade-Off in Foraging and Impair Survival.

The European journal of neuroscience - 1 Sept 2026

Chi Wanhao, Fu Wenqin, Frazier Cristianne R M, Xu Liwen, Beeler Jeff A, Zhuang Xiaoxi

Abstract excerpt

Dopamine plays central roles in reinforcement learning and motivation, allowing animals to evaluate energetic costs and gains for efficient foraging. However, how genetic variation in dopaminergic function influences survival remains poorly understood. Here, we used Drosophila melanogaster, an established model for studying fitness, to investigate the effects of hyperdopaminergic state on survival in...

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Topics

Animals
Drosophila melanogaster
Dopamine
Dopamine Plasma Membrane Transport Proteins
Feeding Behavior
Drosophila Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Learning

Amphetamine

Female

Mutation

Male

Source

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Identifiers

PMID: 42708183
DOI: 10.1111/ejn.70669
PMCID: PMC13551401

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