Article
AA amyloidosis in familial Mediterranean fever: a comparative study of clinical and genetic features between Algerian probands and their relatives.
Rheumatology international - 4 Sept 2026
Khellaf G, Kaci L, Bahriz M R, Ait-Idir D, Boucenna H, Debchi L, Rafa-Debbah H, Rahou Y, Missoum S, Chelghoum S, Benabadji M, Benziane A
Abstract excerpt
AA amyloidosis is the most severe complication of familial Mediterranean fever (FMF). Why some patients develop amyloidosis while genotype-identical relatives remain unaffected is unknown. We assessed whether genetic counseling helps to identify at-risk relatives and whether inflammatory activity, rather than MEFV genotype, drives amyloidosis. We conducted a single-center comparative study (1998-2025) including...
Read the complete abstract on PubMedTopics
- Humans
- Familial Mediterranean Fever
- Female
- Male
- Amyloidosis
- Adult