BRAF V600E-mutated marginal zone lymphoma may exhibit features that partially overlap with hairy cell leukemia.

Abstract excerpt

OBJECTIVES: To establish the occurrence of BRAF mutation in marginal zone lymphomas (MZLs) and study its impact on clinical presentation, pathologic features, and disease classification. METHODS: Conventional histology, immunohistochemistry, flow cytometry, and molecular methods were used. RESULTS: We identified 2 BRAF‑mutated MZL cases: a nodal MZL (NMZL) with BRAF V600E and partial morphologic/immunophenotypic...

Topics

• Humans
• Leukemia, Hairy Cell
• Proto-Oncogene Proteins B-raf
• Lymphoma, B-Cell, Marginal Zone
• Mutation
• Female