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Article

Associations of neighborhood deprivation with breast cancer tumor genomics, targeted treatment use, and survival.

Breast cancer research and treatment - 1 Sept 2026

Podany Emily L, Foffano Lorenzo, Gerratana Lorenzo, Medford Arielle J, Heater Natalie K, Nicolò Eleonora, Tapiavala Shaili, Pontolillo Letizia, Putur Annika, Jaber Diana A, Clifton Katherine, Katakam Nitin, Addison Sarah, Lipsyc-Sharf Marla, Reduzzi Carolina, Ademuyiwa Foluso O, Puglisi Fabio, Gradishar William J, Ma Cynthia X, Bardia Aditya, Cristofanilli Massimo, Davis Andrew A

Abstract excerpt

PURPOSE: Neighborhood environments appear to influence breast cancer biology and outcomes. This study evaluated somatic, treatment, and outcome differences by Area Deprivation Index in patients with metastatic breast cancer. METHODS: Retrospective, population-based cohort study using clinical and genomic data gathered between 2015 and 2024 at four academic institutions in the United States. The outcomes were...

Read the complete abstract on PubMed

Topics

Adult
Aged
Female
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Biomarkers, Tumor

Breast Neoplasms

Circulating Tumor DNA

Genomics

Molecular Targeted Therapy

Mutation

Neighborhood Characteristics

Residence Characteristics

Retrospective Studies

Socioeconomic Disparities in Health

Tumor Suppressor Protein p53

United States

Source

Open in PubMed Open full text

Identifiers

PMID: 42678609
DOI: 10.1007/s10549-026-08068-3
PMCID: PMC13534212

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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