Article
Integrating deep learning and pangenomics to recover missing heritability from wild structural variations.
BMC genomics - 22 Aug 2026
Wang Yiquan, Cai Minnuo, Ma Yahui, Tellier Aurélien, Wei Kai
Abstract excerpt
Crop domestication has induced a severe genetic bottleneck that reduces the adaptive diversity present in modern cultivars. Standard intra-population genomic prediction models reliant on linear reference genomes and SNPs fail to capture the full spectrum of phenotypic variance hidden in wild relatives. Realizing this potential requires broadening the predictive paradigm from selection within narrow breeding...
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