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Article

Acute erythroid leukaemia transformation in polycythaemia vera with leukemic involvement in liver and ascites.

BMJ case reports - 3 Aug 2026

Pagarigan Allison Kaye Lombridas, Sumpansirikul Natcha, Karoopongse Ekapun, Sukpanichnant Sanya

Abstract excerpt

Polycythaemia vera (PV) may rarely evolve into acute erythroid leukaemia (AEL). We herein report a known case of JAK2 p. V617F mutated PV presenting with progressive hepatosplenomegaly, abdominothoracic lymphadenopathy, ascites and various haematological derangements. Rapid diagnostic work-up revealed extensive marrow, hepatic and ascitic fluid infiltration by many CD71+, LMO2+ and p53+ proerythroblasts. Next...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42547260
DOI: 10.1136/bcr-2026-273700

Genes

ASXL1
JAK2
LMO2
TET2
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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