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Article

Unravelling metabolites conferring intestinal protection in asymptomatic first-degree relatives of patients with celiac disease.

Journal of pharmaceutical and biomedical analysis - 15 Dec 2026

Upadhyay Deepti, Das Prasenjit, Dattagupta Siddhartha, Makharia Govind K, Jagannathan Naranamangalam R, Sharma Uma

Abstract excerpt

Celiac disease (CeD) is an autoimmune enteropathy; nearly 60-80% of first-degree relatives (FDRs) of CeD patients carry HLA-DQ2/DQ8 haplotypes; however, only 7.5% of them develop enteropathy. This suggests the modulation of biochemical and molecular mechanisms that might help in maintaining intestinal integrity. Thus, the present study investigated the metabolome of FDRs to gain insight into biochemical...

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Identifiers

PMID: 42531857
DOI: 10.1016/j.jpba.2026.117685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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