Investigation of PDCD1 Gene Polymorphisms and Haplotypes in COVID-19 Severity and Outcome in a Brazilian Population.

doi:10.1002/jmv.71090

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Article

Investigation of PDCD1 Gene Polymorphisms and Haplotypes in COVID-19 Severity and Outcome in a Brazilian Population.

Journal of medical virology - 1 Aug 2026

Moretto Sarah Lott, Cassela Pedro Luis Candido de Souza, Trigo Guilherme Lerner, Lozovoy Marcell Alysson Batisti, Tano Zuleica Naomi, Simão Andrea Name Colado, de Oliveira Karen Brajão

Abstract excerpt

COVID-19 severity and survival are influenced by the host immune response to SARS-CoV-2. Programmed cell death 1 (PD-1), a key immune checkpoint, regulates T-cell activation and antiviral immune balance. Since genetic variability can modulate these responses, we investigated whether the PDCD1 pol...

Topics

Humans
Brazil
Programmed Cell Death 1 Receptor
Haplotypes
Female
Polymorphism, Single Nucleotide
Male
COVID-19
Middle Aged
Gene Frequency
Severity of Illness Index
Adult
SARS-CoV-2
Aged
Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 42530413
DOI: 10.1002/jmv.71090
PMCID: PMC13422133

Genes

PDCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-42530413-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Genetic Predisposition to Disease