Ancient genomics study reveals low HLA diversity in eastern hunter-gatherers.

doi:10.1186/s13059-026-04214-8

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Article

Ancient genomics study reveals low HLA diversity in eastern hunter-gatherers.

Genome biology - 29 Jul 2026

Özer Onur, da Silva Nicolas Antonio, Haller-Caskie Magdalena, Myburgh Daniel Anton, Piezonka Henny, Khramtsova Anastasia, Kostyleva Elena L, Dobrovol'skaya Maria V, Vasilyev Sergei V, Veselovskaya Elizaveta, Meadows John, Nebel Almut, Krause-Kyora Ben

Abstract excerpt

BACKGROUND: Eastern hunter-gatherers (EHG) contributed varying proportions of genetic ancestry to many modern Europeans. However, how this contribution shaped the human leukocyte antigen (HLA) gene diversity remains unexplored. Sakhtysh in western Russia comprises one of the largest EHG-affiliated burial complexes. The site's continuous use offers a rare opportunity to investigate the genetic history, immune-gene...

Topics

Humans
HLA Antigens
Genetic Variation
Russia
Genomics
DNA, Ancient
Alleles
European People
Genetics, Population

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Identifiers

PMID: 42527941
DOI: 10.1186/s13059-026-04214-8
PMCID: PMC13418142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.