Article
A 3D-printed PCL/Ta/Sr-HA composite scaffold enhances osteogenesis and modulates macrophage phenotypic responses.
Colloids and surfaces. B, Biointerfaces - 1 Dec 2026
Wen Zhongchi, Wang Ziqin, Luo Minjie, Li Yuanyuan, Wang Zuzhen, Zhang Yonglong, Wu Weiwei, Xu Yunfei, Zhao Jie, Liu Ying
Abstract excerpt
Complex bone defects present a persistent clinical challenge. Three-dimensional (3D) printing offers a feasible approach for fabricating scaffolds with tailored architectures. In this study, we engineered a series of 3D-printed composite scaffolds by sequentially incorporating tantalum nanoparticles (Ta) and strontium-doped hydroxyapatite (Sr-HA) into a polycaprolactone (PCL) matrix, creating four experimental...
Read the complete abstract on PubMedTopics
- Osteogenesis
- Animals
- Printing, Three-Dimensional
- Tissue Scaffolds
- Polyesters
- Macrophages