Article
3D cryo-printed hierarchical porous scaffolds provide immobilization of surface-functionalized sleep-inspired small extracellular vesicles: synergistic therapeutic strategies for vascularized bone regeneration based on macrophage phenotype modulation and angiogenesis-osteogenesis coupling.
Journal of nanobiotechnology - 19 Dec 2024
Li Xu-Ran, Deng Qing-Song, He Shu-Hang, Liu Po-Lin, Gao Yuan, Wei Zhan-Ying, Zhang Chang-Ru, Wang Fei, Zhu Tong-He, Dawes Helen, Rui Bi-Yu, Tao Shi-Cong, Guo Shang-Chun
Abstract excerpt
Bone defect healing is a multi-factorial process involving the inflammatory microenvironment, bone regeneration and the formation of blood vessels, and remains a great challenge in clinical practice. Combined use of three-dimensional (3D)-printed scaffolds and bioactive factors is an emerging strategy for the treatment of bone defects. Scaffolds can be printed using 3D cryogenic printing technology to create a...
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