Increased high sensitivity C-reactive protein in more severe wheeze/asthma phenotypes in child- and adulthood in ALLIANCE.

doi:10.1186/s12931-026-03840-x

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Article

Increased high sensitivity C-reactive protein in more severe wheeze/asthma phenotypes in child- and adulthood in ALLIANCE.

Respiratory research - 27 Jul 2026

Lagally Lena, Ullemeyer Lena, Omony Jimmy, Gottschau Kristina, Foppiano Francesco, Abdo Mustafa, Veith Vera, Thölken Clemens, Hose Alexander, Maison Nicole, Grychtol Ruth, Dittrich Anna-Maria, Riemann Lennart, Weckmann Markus, König Inke, Kronziel Lea, Illi Sabina, van Koningsbruggen-Rietschel Silke, Rabe Klaus F, Renz Harald, Hansen Gesine, Brinkmann Folke, Kopp Matthias V, von Mutius Erika, Bahmer Thomas, Ege Markus, Skevaki Chrysanthi, Schaub Bianca

Abstract excerpt

BACKGROUND: The relevance of high-sensitivity C-reactive protein (hsCRP), a marker of low-grade systemic inflammation, remains unclear with regard to its association with severity and clinical outcomes in wheeze/asthma. We aimed to assess the role of hsCRP across different phenotypes and severity levels. METHODS: We studied children with preschool wheeze (≥ 2 episodes), and patients with GINA-defined asthma...

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PMID: 42509549
DOI: 10.1186/s12931-026-03840-x
PMCID: PMC13412301

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