Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development and validation of a risk-stratification model for individualized management of leptomeningeal metastases in EGFR- mutant NSCLC (LM-Index).

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2026

Wu Yingxi, Chen Haiyang, Wu Yufeng, Zhao Qi, Wu Xuan, Zhao Yuhua, Guo Lanwei, Li Huiying, Cheng Wanwan, Zhang Longfeng, Xu Weiran, Wang Lili, He Zhen, Yang Sen, Zhang Cuicui, Ma Shuxiang, Li Peng, Li Xiaoyan, Xu Haipeng, Fang Shencun, Yin Zhenyu, Wang Qiming

Abstract excerpt

PURPOSE: Prognosis for patients with EGFR- mutant non-small-cell lung cancer and leptomeningeal metastasis is highly uncertain, complicating treatment decisions. We aimed to develop and validate a multimodal risk score for predicting overall survival to enable risk-stratified management. METHODS: In this retrospective, multicenter study, a derivation cohort (n = 350) and an independent external validation cohort...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung
Share to ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Neoplasms

Share to Meningeal Carcinomatosis

Share to Meningeal Neoplasms

Share to Precision Medicine

Share to Prognosis

Share to Risk Assessment

Source

Identifiers

PMID: 42501706
DOI: 10.1016/j.lungcan.2026.109547

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development and validation of a risk-stratification model for individualized management of leptomeningeal metastases in EGFR- mutant NSCLC (LM-Index).PMID 42501706Read ↗

Survival outcomes and a prognostic nomogram in EGFR-mutant non-small cell lung cancer with leptomeningeal metastasis: a real-world cohort study.Semantic proximity Read ↗

Real-world survival of EGFR-mutated NSCLC with leptomeningeal metastases: prognostic impact of TKIs and local multidisciplinary treatment from the CLM-tree registrySemantic proximity Read ↗

Prognosticators of osimertinib treatment outcomes in patients with EGFR-mutant non-small cell lung cancer and leptomeningeal metastasis.Semantic proximity Read ↗

Treatment and survival of analysis in patients with leptomeningeal metastasis from lung cancerSemantic proximity Read ↗

A Retrospective Real-World Study of Prognostic Factors Associated With EGFR Mutated Lung Cancer With Leptomeningeal Metastasis.Semantic proximity Read ↗

Clinical Outcomes of Patients with Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer with Leptomeningeal Metastasis in the Modern Target Therapy Era.Semantic proximity Read ↗

Molecular characteristics and prognostic factors of leptomeningeal metastasis in non-small cell lung cancer.Semantic proximity Read ↗

Impact of clinicopathologic features on leptomeningeal metastasis from lung adenocarcinoma and treatment efficacy with epidermal growth factor receptor tyrosine kinase inhibitor.Semantic proximity Read ↗

The Brain-Lung Immunotherapy Prognostic (BLIP) Score: A Novel Robust Tool for Prognostication in Non-Small Cell Lung Cancer Patients with Brain MetastasesSemantic proximity Read ↗

Leptomeningeal Metastases in Non-small Cell Lung Cancer: Optimal Systemic Management in NSCLC With and Without Driver Mutations.Semantic proximity Read ↗

Effectiveness of high-dose third-generation EGFR-tyrosine kinase inhibitors in treating EGFR-mutated non-small cell lung cancer patients with leptomeningeal metastasis.Semantic proximity Read ↗

Salvage dacomitinib plus intraventricular pemetrexed for leptomeningeal metastasis after failure of third‑generation EGFR‑TKIs in EGFR‑mutant NSCLC: an ambispective cohort study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.