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Article

Childhood Adversity and Cardiovascular Disease Risk: Unraveling Plasma Proteomic Pathways and Moderating Role of Genetic Predisposition.

Journal of the American Heart Association - 4 Aug 2026

Wang Jiang-Yan, Liu Chang, Jia Xiao-Yu, Wang Jia-Ning, Jia Cun-Xian, Liu Bao-Peng

Abstract excerpt

BACKGROUND: Childhood adversity (CA) is associated with cardiovascular disease (CVD). Proteomic profiling may help elucidate underlying mechanisms. This study aimed to explore how CA and genetic risk jointly impact CVD and the potential role of proteomic biomarkers. METHODS: A total of 14 508 participants without baseline CVD and with available proteomics data from the UK Biobank were included. CA was assessed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42500902
DOI: 10.1161/JAHA.125.048564

Genes

AHNAK
CD302
CD83

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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