Adding local gyro-knife radiotherapy to EGFR-TKI improves outcomes in EGFR-mutant NSCLC.

doi:10.1016/j.ejso.2026.112028

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Article

Adding local gyro-knife radiotherapy to EGFR-TKI improves outcomes in EGFR-mutant NSCLC.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Sept 2026

Zhang Zhinan, Tao Xue, Ju Hong, Sun Xiaoyan, Lu Shuangling, Tong Bin

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are standard first-line therapy for EGFR-mutant non-small cell lung cancer (NSCLC), yet acquired resistance, particularly local progression, remains a major clinical challenge. The additive role of local stereotactic radiotherapy (e.g., Gyro-Knife-based SBRT) is not well defined. METHODS: In this retrospective cohort study, 82...

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Carcinoma, Non-Small-Cell Lung
Combined Modality Therapy
ErbB Receptors
Lung Neoplasms
Neoplasm Staging

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinase Inhibitors

Radiosurgery

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Open in PubMed

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PMID: 42492466
DOI: 10.1016/j.ejso.2026.112028

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.