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Reassessment of PRRSV-2 ORF5 sequence diversity in Japan identifies a previously unrecognized candidate lineage-level clade.

Archives of virology - 23 Jul 2026

Taira Osamu, Takai Ryosuke, Yonezawa Yoriko, Tsutsumi Nobuyuki, Sugiura Katsuaki

Abstract excerpt

Porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2) exhibits extensive genetic diversity, and ORF5-based classification provides a standardized framework for global molecular surveillance. In a previous nationwide study in Japan, lineage 4 (L4) was identified as a dominant lineage exhibiting unexpectedly high genetic diversity. This observation motivated a focused reassessment of L4-assigned...

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PMID: 42489934
DOI: 10.1007/s00705-026-06696-0

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