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Article

Whole genome and exome sequencing of pancreatic neuroendocrine tumour to investigate PRRT response.

Endocrine-related cancer - 1 Aug 2026

Boehm Emma, Flynn Aidan, Caneborg Alex, Hatzimihalis Athena, Hogg Annette, Waldeck Kelly, Jackett Louise, Prall Owen W J, Mitchell Catherine, Kong Grace, Michael Michael, Akhurst Tim, Thomson Benjamin N J, Murray William K, Chin Kwang, Lawrence Ben, Print Cristin G, Vissers Joseph H A, Grimmond Sean M, Tothill Richard W, Hicks Rodney J

Abstract excerpt

Patients with pancreatic neuroendocrine tumours (PNETs) often have similar baseline clinical characteristics, including grade and molecular imaging phenotype, yet have highly variable responses to peptide receptor radionuclide therapy (PRRT). To identify genomic alterations and mutational patterns associated with PRRT treatment response and acquired somatic changes following PRRT exposure, whole genome or exome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42473856
DOI: 10.1530/ERC-26-0207
PMCID: PMC13452026

Genes

ATRX
DAXX
MEN1
PSIP1
TBL1X

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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