Article
Hepatitis C Virus Enhances Lysosome-Associated Membrane Protein 2 A Transcription Through Nuclear Factor Erythroid 2-Related Factor 2 to Support Viral Replication.
Microbiology and immunology - 1 Sept 2026
Xu Zihan, Matsui Chieko, Septianastiti Maria Alethea, Puspitasari Fransisca, Deng Lin, Abe Takayuki, Shoji Ikuo
Abstract excerpt
Hepatitis C virus (HCV) establishes persistent infection by rewiring host stress-response pathways. Chaperone-mediated autophagy (CMA) contributes to HCV replication, but it remains unclear whether HCV regulates lysosome-associated membrane protein 2 A (LAMP-2A), the rate-limiting receptor for CMA. Here, we examined LAMP-2A regulation in HCV-infected Huh-7.5 cells. HCV infection increased LAMP-2A promoter...
Read the complete abstract on PubMedTopics
- Hepacivirus
- Autophagy
- Lysosomal-Associated Membrane Protein 2
- Virus Replication
- NF-E2-Related Factor 2