Article
Genetics and clinical landscape of pediatric monogenic diabetes in consanguineous cohort: high diagnostic yield and recessive burden.
Diabetes research and clinical practice - 1 Sept 2026
Shaikh Adnan Al, Alsagheir Afaf, Bahha Abdullah Talal, Alharthi Mohammed, Bunyan Abdulhameed Al, Alyahyawi Naseem Yahya, Harbi Tahani Al, Al Hakim Sarah Y, Mohammed Moneera, Noaim Khalid Al, Majrashi Nada, Almutair Angham, Al-Hamed Mohamed H
Abstract excerpt
BACKGROUND: Monogenic diabetes mellitus (MDM) comprises a heterogeneous group of rare disorders caused by single-gene defects. Data from highly consanguineous Middle Eastern populations remain scarce, which limits the application of precision medicine in these regions. OBJECTIVE: To characterize the genetic spectrum, clinical features, and inheritance patterns of MDM within a large Saudi Arabian cohort. METHODS:...
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