Morphologic, Immunohistochemical, and Molecular Features of Laser-Ablated Thyroid Nodules: Diagnostic Pitfalls and Differential Diagnosis with Thyroid Carcinoma.

doi:10.3390/ijms27135880

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Article

Morphologic, Immunohistochemical, and Molecular Features of Laser-Ablated Thyroid Nodules: Diagnostic Pitfalls and Differential Diagnosis with Thyroid Carcinoma.

International journal of molecular sciences - 30 Jun 2026

Tralongo Pietro, Russotto Fernanda, Zuccalà Valeria, Fiorentino Vincenzo, Micali Marina Gloria, Franchina Mariausilia, Pepe Ludovica, Giordano Walter, Ricciardi Gabriele, Ballato Mariagiovanna, Germanà Emanuela, Magliolo Emilia, Ristagno Serenella, Rossi Esther Diana, Martini Maurizio, Fadda Guido

Abstract excerpt

Thermal ablation (TA) is an increasingly adopted minimally invasive treatment for benign thyroid nodules. However, TA induces marked histological alterations that may simulate thyroid malignancy, creating significant diagnostic pitfalls for pathologists. The present study expands our previous institutional series and further characterizes the morphologic, immunohistochemical, and molecular features of thermally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42450153
DOI: 10.3390/ijms27135880
PMCID: PMC13362253

Genes

BRAF
PIK3CA
RET
TERT

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