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Characterization of oseltamivir-resistant A(H5N1) clade 2.3.4.4b, genotype D1.1 variants identified in poultry farms of British Columbia, Canada.

Emerging microbes & infections - 1 Dec 2026

Cochin Maxime, Abed Yacine, Vendramelli Robert, Dionne Katrina, Bourassa Catherine, Laroche Geneviève, Chan Rose, Truong Thang, Signore Anthony, Berhane Yohannes, Côté Marceline, Finzi Andres, Kobasa Darwyn, Boivin Guy

Abstract excerpt

Highly pathogenic avian influenza A(H5N1) viruses of clade 2.3.4.4b, genotype D1.1, are responsible for widespread outbreaks in poultry and continue to cause sporadic, sometimes severe, human infections. Herein, we characterized a wild-type (WT) influenza A(H5N1) D1.1 isolate (BC-H5N1-WT) and its H275Y neuraminidase (NA) variant (BC-H5N1-H275Y), both of which emerged on farms in British Columbia, Canada, during...

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PMID: 42419257
DOI: 10.1080/22221751.2026.2686474
PMCID: PMC13353464

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