Fluoropyrimidine Cardiotoxicity: Role of Uridine Triacetate and Pharmacogenomic Insights from a Case of 5-FU-Induced Cardiogenic Shock.

doi:10.1097/FJC.0000000000001853

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Article

Fluoropyrimidine Cardiotoxicity: Role of Uridine Triacetate and Pharmacogenomic Insights from a Case of 5-FU-Induced Cardiogenic Shock.

Journal of cardiovascular pharmacology - 1 Sept 2026

Filomia Simone, Del Buono Marco G, Saponara Gianluigi, Aurigemma Cristina, Marano Riccardo, Moliterno Eleonora, Tortora Giampaolo, Minucci Angelo, Salvatore Lisa, Soave Paolo M, Burzotta Francesco, Sanna Tommaso

Abstract excerpt

ABSTRACT: Fluoropyrimidines, including 5-fluorouracil and capecitabine, are widely used antimetabolite agents and remain central to the treatment of several solid tumors, particularly gastrointestinal malignancies. However, they are a well-established cause of chemotherapy-related cardiotoxicity. Although coronary vasospasm is the best recognized manifestation, fluoropyrimidine cardiotoxicity encompasses a broad...

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Topics

Humans
Female
Shock, Cardiogenic
Cardiotoxicity
Fluorouracil

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Antineoplastic Combined Chemotherapy Protocols

Antimetabolites, Antineoplastic

Pharmacogenomic Variants

Uridine

Dihydrouracil Dehydrogenase (NADP)

Thymidylate Synthase

Treatment Outcome

Genetic Predisposition to Disease

Ventricular Function, Left

Leucovorin

Pharmacogenomic Testing

Acetates

Source

Open in PubMed

Identifiers

PMID: 42407011
DOI: 10.1097/FJC.0000000000001853

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