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Article

Association of CLCA4 genetic variation with non-obstructive azoospermia and its potential interaction with Y-chromosome microdeletions.

Molecular biology reports - 3 Jul 2026

Al-Azzawi Khalid Suhail A, Jaber Nawar R, Algafari Rebah N, Ramadhan Rehab S

Abstract excerpt

BACKGROUND: Non-obstructive azoospermia (NOA) is a severe form of male infertility with heterogeneous genetic determinants. While Y-chromosome microdeletions are established contributors, the role of autosomal variants in modulating disease susceptibility and phenotypic variability remains poorly understood. METHODS: A case-control study was conducted comprising 87 NOA patients and 50 fertile controls. CLCA4...

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Azoospermia
Case-Control Studies
Chromosome Deletion
Chromosomes, Human, Y
Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Infertility, Male

Sex Chromosome Aberrations

Source

Identifiers

PMID: 42397533
DOI: 10.1007/s11033-026-12284-x

Genes

CLCA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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