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Sacchaindols A-C, Dimeric Alkaloids with Anti-inflammatory Activity from Marine Sediment-Derived Mutant Strain Saccharopolyspora erythraea SCSIO 07745/Δspo11.

Organic letters - 17 Jul 2026

Li Kunlong, Luo Xiaowei, Li Peihai, Sun Changli, Ma Xuan, Shang Zhuo, Liu Dehui, Ma Junying, Zhu Hongjie, Ju Jianhua

Abstract excerpt

Two novel types of dimeric alkaloids were isolated from the marine sediment-derived mutant strain Saccharopolyspora erythraea SCSIO 07745/Δspo11. Among them, sacchaindol A (1) represents a previously unreported class of dimeric aminoquinolinone alkaloids, whereas sacchaindols B (2) and C [(±)-3] comprise a rare fused 6/6/5/5 tetracyclic indole alkaloid framework. Their structures were elucidated using a...

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Alkaloids
Anti-Inflammatory Agents
Crystallography, X-Ray
Geologic Sediments
Molecular Conformation

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Molecular Structure

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PMID: 42392986
DOI: 10.1021/acs.orglett.6c02104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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