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Article

Novel RHOXF1 mutation causes male infertility by inducing severe oligoasthenozoospermia.

Reproductive biology - 1 Sept 2026

Jin Yinshan, Shi Ying, Cui Yuanqing, Chen Jie, Zhang Xuebao, Wang Xiong

Abstract excerpt

Oligoasthenozoospermia (OAT) is a common cause of male infertility, with most OAT patients resulting from genetic defects. In this study, we recruited a severe OAT patient and his family for genetic analysis, identifying a heterozygous RHOXF1 mutation (c.412 G>A p.Glu138Lys) in the patient and his brother, inherited from their mother who carried a heterozygous RHOXF1 mutation. The RHOXF1 mutation (c.412 G>A...

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Share to Asthenozoospermia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42379029
DOI: 10.1016/j.repbio.2026.101242

Genes

OAT
RHOXF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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