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Imprecise Cas12a/ssODN-Mediated Editing of eIF4E1 Confers Dominant-Negative Resistance to Potato Virus Y in Solanum tuberosum.

Molecular plant pathology - 1 Jul 2026

Lucioli Alessandra, Tavazza Raffaela, Molnar Attila, Ilardi Vincenza, Přibylová Adéla, Tavazza Mario

Abstract excerpt

Mutants in the eukaryotic initiation factor 4E (eIF4E) gene family provide recessive resistance to plant viruses. Previously, we demonstrated that knocking out SteIF4E1 potato alleles (A, B, B, B1) resulted in limited resistance to a necrogenic PVY isolate (NTN). Expanding on this, we used a non-transgenic method employing Cas12a and a single-stranded oligodeoxynucleotide (ssODN) as a repair template to introduce...

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Base Sequence
Disease Resistance
Eukaryotic Initiation Factor-4E
Plant Diseases
Plant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plants, Genetically Modified

Solanum tuberosum

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PMID: 42374852
DOI: 10.1111/mpp.70305
PMCID: PMC13315812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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