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Early diabetes-like phenotypes in germ-free mice induced by gut microbiota from patients with type 2 diabetes.

Animal models and experimental medicine - 1 Jun 2026

Feng Jianghao, Liu Xing, Zhu Hua, Yang Yun, Liu Wei, Jiang Xiaoliang, Yang Zhiwei

Abstract excerpt

BACKGROUND: The contribution of gut microbiota to the early stage of type 2 diabetes (T2D) remains incompletely understood. This study established a germ-free mouse model colonized with gut microbiota from donors with T2D to determine whether diabetes-associated microbiota could induce early diabetes-like phenotypes. METHODS: Human fecal samples were collected from 18 healthy donors and 14 donors with T2D for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42359605
DOI: 10.1002/ame2.70229
PMCID: PMC13383894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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