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Paradoxical Immune Phenotypes and Dual-State Immune Regulators in Plants: The GSL5 Case Study.

International journal of molecular sciences - 15 Jun 2026

Gao Lixia, Zuo Rong, Zhang Xiong

Abstract excerpt

Plant immune genes are traditionally classified as resistance genes, susceptibility genes, or positive/negative regulators of defense. However, this framework does not fully explain a subset of immune-associated genes that display paradoxical disease phenotypes, in which genetic disruption enhances resistance despite the normal involvement of these genes in defense-related processes. GSL5/PMR4 is a representative...

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Arabidopsis Proteins
Disease Resistance
Gene Expression Regulation, Plant
Glucosyltransferases
Plant Diseases

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PMID: 42353095
DOI: 10.3390/ijms27125375
PMCID: PMC13300646

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