Article
Exploring Dystrophin Expression and Mutations in the DMD and Dystrophin-Glycoprotein Complex Genes as Prognostic Factors in Leiomyosarcomas.
International journal of molecular sciences - 11 Jun 2026
Salazar Juliana, Cerdà Paula, Artigas Alícia, Orellana Ruth, González Allan, Terés Raúl, Arranz María J, Bagué Silvia, Fumagalli Caterina, González José Antonio, Peiró Ana, González-Quereda Lidia, Rodríguez María José, Gallardo Eduard, Aguado María, Sebio Ana
Abstract excerpt
Molecular factors influencing prognosis in leiomyosarcomas (LMS) remain poorly understood. Given that LMS arise from smooth muscle and that the dystrophin gene (DMD) has been suggested as a tumor suppressor in this tumor type, this study investigated dystrophin expression and somatic mutations in DMD, and dystrophin-glycoprotein complex (DGC) and dysferlin (DYSF) coding genes as prognostic biomarkers in LMS....
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