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Low-Abundance and Fragmentary Helicobacter pylori DNA Detected in Phenotypically Negative Gastric Biopsies Using Targeted Sequencing.

Biomolecules - 22 May 2026

Mbaya-Tshibangu Fabien, Cimuanga-Mukanya Alain, Tshibangu-Kabamba Evariste, Kayiba-Kalenda Nadine, Kalenga-Ngomba Tressy, Ngoma-Kisoko Patrick de Jesus, Revathi Gunturu, Akada Junko, Mbiya-Mukinayi Benoît, Kabongo Augustin Tshibaka, Disashi-Tumba Ghislain, Matsumoto Takashi, Yamaoka Yoshio

Abstract excerpt

Accurate detection and monitoring of antimicrobial resistance (AMR) in Helicobacter pylori mainly rely on phenotypic methods and culture, which can sometimes fail when bacterial load is low or after recent treatment. We investigated whether gastric biopsies classified as H. pylori-negative by standard diagnostic techniques still contain detectable bacterial DNA, including regions linked to AMR, and assessed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42352236
DOI: 10.3390/biom16060765
PMCID: PMC13296529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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