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Article

Transposase-Associated Variation near tnaA in Porphyromonas gingivalis Is Linked to Indole Production and Virulence-Associated Gene Expression.

Pathogens (Basel, Switzerland) - 9 Jun 2026

Wei Li, Xie Chengjia, Ren Qingnan, Zhi Mengfan, Shen Song, Gu Xiufeng, Feng Qiang, Sun Tianyong

Abstract excerpt

Indole, a volatile metabolite produced by bacterial tryptophanase (encoded by tnaA) during tryptophan metabolism, contributes to oral malodor and may influence the progression of periodontitis. However, the genetic features underlying strain-specific indole production and its association with bacterial virulence remain unclear. Analysis of a previously published periodontitis cohort revealed that periodontitis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42347229
DOI: 10.3390/pathogens15060617
PMCID: PMC13305171

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