Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Case Report: Haemopoietic stem cell transplantation in refractory paediatric RAS-associated lymphoproliferative disorder.

Frontiers in immunology - 1 Jan 2026

Senthil Srividhya, Matalliotakis Michail G, Hughes Stephen, Arkwright Peter D, Shenoy Mohan, Wynn Robert

Abstract excerpt

RAS-associated lymphoproliferative disorder (RALD), caused by acquired gain-of-function mutations in Kirsten rat sarcoma KRAS or Neuroblastoma rat sarcoma NRAS, is an orphan disease with very few cases reported worldwide. The most common presenting feature is autoimmune cytopenia, which is generally documented to be responsive to immunosuppression. We describe two cases of RALD in which associated autoimmunity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GTP Phosphohydrolases
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant

Share to Lymphoproliferative Disorders

Share to Membrane Proteins

Share to Mutation

Share to ras Proteins

Share to Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 42344933
DOI: 10.3389/fimmu.2026.1850700
PMCID: PMC13287018

Genes

KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Case Report: Haemopoietic stem cell transplantation in refractory paediatric RAS-associated lymphoproliferative disorder.PMID 42344933Read ↗

Clinical Spectrum of Ras-Associated Autoimmune Leukoproliferative Disorder (RALD).Semantic proximity Read ↗

Cutaneous involvement in an 8-year-old boy with Ras-associated autoimmune leucoproliferative disorder (RALD).Semantic proximity Read ↗

Summary and Analysis of 13 RAS-Associated Autoimmune Leukoproliferative Disease Clinical FeaturesSemantic proximity Read ↗

The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus.Semantic proximity Read ↗

[Ras-associated autoimmune leukoproliferative disorder: a report of 2 cases and literature review].Semantic proximity Read ↗

JMML and RALD (Ras-associated autoimmune leukoproliferative disorder): common genetic etiology yet clinically distinct entities.Semantic proximity Read ↗

Ras‐associated autoimmune lymphoproliferative disorderSemantic proximity Read ↗

Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation.Semantic proximity Read ↗

RAS-associated Autoimmune Leukoproliferative Disease (RALD-KRAS) Consistent with the Clinical Diagnosis of Rosai-Dorfman Disease: A 15-year Follow-up.Semantic proximity Read ↗

Somatic mosaicism for a NRAS mutation associates with disparate clinical features in RAS-associated leukoproliferative disease: a report of two cases.Semantic proximity Read ↗

Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report.Semantic proximity Read ↗

Sirolimus is effective in autoimmune lymphoproliferative syndrome-type III: A pedigree case report with homozygous variation PRKCD.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.