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Article

Impact of genotype on histopathology and clinical characters in a Chinese cohort with obstructive hypertrophic cardiomyopathy.

Genomics - 1 Jul 2026

Yin Kunlun, Sun Yang, Zhao Huazheng, Yang Hang, Meng Yanhai, Li Tianjiao, Li Wenke, Han Bianmei, Liu Xuewen, Wang Shuiyun, Zhou Zhou

Abstract excerpt

BACKGROUND: While genotype has been related to specific clinical phenotype in hypertrophic cardiomyopathy (HCM), the critical intervening role of histopathological damage remains unclear. Specifically, how graded variant pathogenicity drives the spectrum of myocardial tissue alterations, which in turn mediate the severity and precocity of clinical features is poorly defined. METHODS: A...

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Identifiers

PMID: 42342168
DOI: 10.1016/j.ygeno.2026.111286

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