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Article

NF2/Merlin Immunohistochemistry Helps Distinguish Collecting Duct Carcinoma From Upper Tract Urothelial Carcinoma.

The American journal of surgical pathology - 1 Oct 2026

Baraban Ezra, Palsgrove Doreen N, Yol Cansu, Al-Ahmadie Hikmat, Argani Pedram

Abstract excerpt

Collecting duct carcinoma (CDC) and upper tract urothelial carcinoma (UTUC) can exhibit overlapping morphologic features, particularly in limited biopsies, creating diagnostic challenges with significant therapeutic implications. Recent molecular studies have identified recurrent NF2 alterations in CDC, whereas pathogenic NF2 alterations are uncommon in UTUC. We evaluated the utility of NF2/Merlin...

Read the complete abstract on PubMed

Topics

Humans
Immunohistochemistry
Biomarkers, Tumor
Diagnosis, Differential
Female
Kidney Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aged

Carcinoma, Renal Cell

Neurofibromin 2

Male

Predictive Value of Tests

Middle Aged

Aged, 80 and over

Mutation

Carcinoma, Transitional Cell

Urothelium

Adult

Source

Identifiers

PMID: 42340165
DOI: 10.1097/PAS.0000000000002584

Genes

NF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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