Persistent selection on size explains micro- and macroevolutionary alignments in fly wings.

Abstract excerpt

The alignment among mutational variance (M), standing genetic variance (G), and macroevolutionary divergence (R) in Drosophila wing shape poses a rate paradox under a simple constraint hypothesis: Evolution follows mutational lines of least resistance, yet proceeds orders of magnitude slower than the abundant genetic variation would permit. This is difficult to reconcile with a simple constraint view in which...

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