Article
Searching for New Genes That Cause Usher Syndrome.
American journal of ophthalmology - 1 Oct 2026
Moshiri Ala, Kasiri Niusha, Shea Michael, Ali Layla, Yang Benjamin, Shao Andy, Clary Dave, Flenniken Ann M, Eskandarian Mohammad, Amarie Oana V, Becker Lore, Sangermano Riccardo, Place Emily M, Bujakowska Kinga M, Huckfeldt Rachel M, Berberovic Zorana, Bour Raphaël, Riet Fabrice, Brown Steve D, D'Souza Abigail, Fuchs Helmut, Gailus-Durner Valerie, Guimond Alain, Hérault Yann, Angelis Martin Hrabě DE, Lux Aline, Mittelhaeuser Christophe, Nutter Lauryl M J, Palkova Marcela, Lindovsky Jiri, Petit-Demouliere Benoit, Prochazka Jan, Bradaschia Vivian, Kelsey Lois, McKerlie Colin, Raishbrook Miles Joseph, Sedlacek Radislav, Lanoue Louise, Lloyd K C Kent, Roux Michel J, Bermingham-McDonogh Olivia
Abstract excerpt
PURPOSE: The purpose of this project was to identify novel Usher syndrome (USH) candidate genes from phenotyping data of 9139 knockout (KO) mouse lines. METHODS: We evaluated phenotype data for concurrent retinopathy and hearing abnormalities in single-gene KO mice generated by the International Mouse Phenotyping Consortium (IMPC). A search was performed to determine whether each gene had been previously...
Read the complete abstract on PubMedTopics
- Animals
- Usher Syndromes