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Article

Exploring precision risk in pediatric vesicoureteral reflux: Innate immune gene variations and reflux outcomes in the RIVUR cohort.

Journal of pediatric urology - 1 Oct 2026

Kim Jin Kyu, Misseri Rosalia, Roth Joshua, Schwaderer Andrew, Zhang Shaobo, Hains David S

Abstract excerpt

INTRODUCTION: Children with vesicoureteral reflux (VUR) are at increased risk for morbidity from recurrent urinary tract infections (UTIs), yet the factors influencing spontaneous VUR resolution remain poorly defined. This study evaluates whether genetic variations in key urinary innate immune effectors (DEFA1A3, DMBT1, and RNASE7) influences VUR resolution and interacts with prophylaxis to alter clinical...

Read the complete abstract on PubMed

Topics

Humans
Female
Vesico-Ureteral Reflux
Male
Immunity, Innate
Child, Preschool

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Child

DNA-Binding Proteins

alpha-Defensins

Receptors, Cell Surface

Tumor Suppressor Proteins

Urinary Tract Infections

Genetic Variation

DNA Copy Number Variations

Risk Assessment

Genotype

Cohort Studies

Infant

Source

Identifiers

PMID: 42302586
DOI: 10.1016/j.jpurol.2026.106068

Genes

DMBT1
RNASE7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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