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Article

Clinical Utility of Rapid Whole-Genome Sequencing in Hospitalized Adults With Unexplained Neurologic Presentations.

Neurology - 14 Jul 2026

Amanat Man, Toledano Michel, Schimmenti Lisa A, Pichurin Pavel N, Lanpher Brendan C, Deyle David R, Tan Queenie K G, Iverson Gabrielle, Cera Alanna, Gavrilova Ralitza, Dhamija Radhika

Abstract excerpt

BACKGROUND AND OBJECTIVES: Adults with unexplained neurologic presentations often undergo extensive evaluations without timely diagnosis. Evidence supporting the clinical utility of rapid whole-genome sequencing (rWGS) in hospitalized adult populations remains limited. We evaluated the diagnostic yield of rWGS in adults hospitalized for unexplained neurologic manifestations and assessed clinical predictors of a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42302220
DOI: 10.1212/WNL.0000000000218151
PMCID: PMC13312935

Genes

NLRP12
CCM2
CNBP
FGF14
FLNA
HEXA
HUWE1
IFIH1
NOTCH1
PRNP
PTPN11

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