Article
Proteomic signals are not equal clinical phenotypes: redefining evidence standards in arbovirus-SARS-CoV-2 cross-reactivity.
Frontiers in immunology - 1 Jan 2026
Salvador Ibarra Ibzan Jahzeel, Mora Guzmán Zoila, Borrás Enríquez Anahí Jobeth, Alpuche Juan, Castañeda-Hernández Gilberto, Pérez-Campos Eduardo, Hernández-Huerta María Teresa, Cabrera-Fuentes Hector Alejandro
Abstract excerpt
The interaction between SARS-CoV-2 and dengue virus represents a biologically plausible yet clinically unresolved challenge in regions where both pathogens co-circulate. Emerging omics-based studies propose that prior SARS-CoV-2 exposure may shape a distinct dengue phenotype through immune imprinting and antibody-dependent mechanisms. However, whether these molecular signals translate into clinically meaningful...
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