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Article

The geographic structure of pathogen resistance phenotypes under balancing selection.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 11 Jun 2026

Ebert Dieter, Krebs Michelle

Abstract excerpt

The Red Queen model of host-parasite coevolution is based on time-lagged negative frequency-dependent selection resulting from highly specific interactions of the antagonists within populations. This model has been the preferred theory for explaining the elevated levels of genetic diversity and even trans-species polymorphisms found in the disease genes of many organisms, including humans. Several genomic...

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PMID: 42272389
DOI: 10.1098/rstb.2025.0183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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