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The Evolution of Extreme Genetic Variability in a Parasite-Resistance Complex.

Genome biology and evolution - 9 Oct 2024

Naser-Khdour Suha, Scheuber Fabian, Fields Peter D, Ebert Dieter

Abstract excerpt

Genomic regions that play a role in parasite defense are often found to be highly variable, with the major histocompatibility complex serving as an iconic example. Single nucleotide polymorphisms may represent only a small portion of this variability, with Indel polymorphisms and copy number variation further contributing. In extreme cases, haplotypes may no longer be recognized as orthologous. Understanding the...

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PMID: 39391977
DOI: 10.1093/gbe/evae222
PMCID: PMC11500718

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