Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Keeping Pace with the Red Queen: Identifying the Genetic Basis of Susceptibility to Infectious Disease.

Genetics - 1 Feb 2018

MacPherson Ailene, Otto Sarah P, Nuismer Scott L

Abstract excerpt

Genome-wide association studies are widely used to identify "disease genes" conferring resistance/susceptibility to infectious diseases. Using a combination of mathematical models and simulations, we demonstrate that genetic interactions between hosts and parasites [genotype-by-genotype (G × G) interactions] can drastically affect the results of these association scans and hamper our ability to detect genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Communicable Diseases
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Host-Parasite Interactions

Share to Host-Pathogen Interactions

Share to Models, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 29223971
DOI: 10.1534/genetics.117.300481
PMCID: PMC5788537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Keeping Pace with the Red Queen: Identifying the Genetic Basis of Susceptibility to Infectious Disease.PMID 29223971Read ↗

Uncovering the Genomic Basis of Infection Through Co-genomic Sequencing of Hosts and Parasites.Semantic proximity Read ↗

Uncovering the genomic basis of infection through co-genomic sequencing of hosts and parasitesSemantic proximity Read ↗

Disentangling the influence of parasite genotype, host genotype and maternal environment on different stages of bacterial infection in Daphnia magna.Semantic proximity Read ↗

The Red Queen lives: Epistasis between linked resistance loci.Semantic proximity Read ↗

A Two-Locus System with Strong Epistasis Underlies Rapid Parasite-Mediated Evolution of Host Resistance.Semantic proximity Read ↗

Rapid evolution of a large structural polymorphism during a bacterial epidemic.Semantic proximity Read ↗

Genetic basis of resistance in hosts facing alternative infection strategies by a virulent bacterial pathogen.Semantic proximity Read ↗

The genetic basis of resistance and matching-allele interactions of a host-parasite system: The Daphnia magna-Pasteuria ramosa model.Semantic proximity Read ↗

Genetic analysis of infectious diseases: estimating gene effects for susceptibility and infectivity.Semantic proximity Read ↗

QTL study reveals candidate genes underlying host resistance in a Red Queen model system.Semantic proximity Read ↗

The Evolution of Extreme Genetic Variability in a Parasite-Resistance Complex.Semantic proximity Read ↗

The timings of host diapause and epidemic progression mediate host genetic diversity and future epidemic size in Daphnia-parasite populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.