Article
Revisiting Spontaneous Keloids: Aetiology, Genetics and Evidence for a Polygenic Pathogenesis.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society - 1 Jan 2026
Budhiraja Anuj, Shawa Harrison, Mehta Alisha, Dafinone Mirabel, Tchanque-Fossuo Catherine N, Kiuru Maija, Dahle Sara, Isseroff Rivkah
Abstract excerpt
Keloids are abnormal scars resulting from dysregulated wound healing extending beyond the original injury. While typically triggered by trauma, rare cases of spontaneous keloid formation challenge this paradigm and suggest potential endogenous drivers. This study synthesises all reported cases to date and explores pathogenic mechanisms underlying their diverse etiologies. Special emphasis is placed on syndromic...
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