A randomised study of encorafenib, cetuximab, and FOLFIRI versus FOLFIRI with or without bevacizumab in BRAF V600E-mutant colorectal cancer: BREAKWATER Cohort 3.

doi:10.1016/j.annonc.2026.04.017

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A randomised study of encorafenib, cetuximab, and FOLFIRI versus FOLFIRI with or without bevacizumab in BRAF V600E-mutant colorectal cancer: BREAKWATER Cohort 3.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Aug 2026

Kopetz S, Tabernero J, Lonardi S, Shen L, Wasan H S, Yoshino T, Van Cutsem E, Kim T W, Eng C, Ciardiello F, Desai J, Maughan T S, Yaeger R, Usari T, Zhang Xiaoxi, Beyzarov E, Mori A, Whalley E, Zhang Xiaosong, Elez E

Abstract excerpt

BACKGROUND: Encorafenib + cetuximab (EC) and mFOLFOX6 or irinotecan, leucovorin, and fluorouracil (FOLFIRI) is approved in several countries for BRAF V600E-mutant metastatic colorectal cancer (mCRC) based on results from the BREAKWATER trial. PATIENTS AND METHODS: In BREAKWATER Cohort 3, eligible patients with previously untreated BRAF V600E-mutant mCRC were randomly assigned 1:1 to receive EC+FOLFIRI or FOLFIRI...

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PMID: 42219860
DOI: 10.1016/j.annonc.2026.04.017

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