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Article

Identification of moderate effect size genes in autism spectrum disorder through a novel gene pairing approach.

Communications biology - 30 May 2026

Caballero Madison, Satterstrom F Kyle, de Rubeis Silvia, Buxbaum Joseph D, Mahjani Behrang

Abstract excerpt

Autism Spectrum Disorder (ASD) arises from complex genetic and environmental factors, with inherited genetic variation playing a substantial role. This study introduces a novel approach to uncover moderate effect size (MES) risk genes in ASD, which individually do not meet the ASD liability threshold but contribute to risk when paired with another MES risk gene. Analyzing 10,795 families from the SPARK dataset,...

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PMID: 42218271
DOI: 10.1038/s42003-026-10380-z
PMCID: PMC13518923

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