Enhanced production, activity and deregulation of β-galactosidase in a new mutant strain Bifidobacterium longum BIM B-813 D: Characterization and industrial potential.

Abstract excerpt

This study aimed to engineer a Bifidobacterium longum strain with enhanced production of the industrially relevant enzyme β-galactosidase. Initial screening of 12 bifidobacterial strains identified B. longum Cf as a high-activity candidate (340 Miller units), though its enzyme synthesis was strongly suppressed by glucose (98%). The parent strain's specific growth rate was 0.36 h-1, with a maximum β-galactosidase...

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