Article
Zinc deficiency and sarcopenia define a metabolic frailty phenotype predicting hepatic encephalopathy and early mortality in cirrhosis.
Metabolic brain disease - 28 May 2026
Méndez-Guerrero Osvely, Carranza-Carrasco Anaisa, Guerrero-Guerrero Rodrigo, Castillo-Martínez Lilia, Del Razo-Olvera Fabiola M, Juárez-Martínez Liliana, Otero-Otero Rodrigo, Estanes-Hernández Alma, Clark Patricia, Aguilar-Salinas Carlos A, Torre Aldo, Castro-Narro Graciela E, Navarro-Alvarez Nalu
Abstract excerpt
Cirrhosis is characterized by progressive metabolic vulnerability, yet early indicators of clinical decompensation remain limited. Zinc, a key cofactor in ammonia detoxification and protein metabolism, may reflect and contribute to metabolic frailty when deficient. We aimed to determine whether zinc deficiency and sarcopenia jointly define a metabolic frailty phenotype that predicts overt hepatic encephalopathy...
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