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Gut microbiota-metabolite axis in gastric cancer: Genetic causality and Ruminococcus subgroup shifts.

Cancer genetics - 1 Sept 2026

Ji Jun, Feng Xiaojing, Sun Ying, Cai Qu, Shaw Minakshmi, Yu Beiqin, Zhang Jun

Abstract excerpt

Observational studies have long suggested an association between gut microbiota dysbiosis and gastric cancer, yet the causal relevance and underlying biological pathways remain poorly defined. Here, we applied a comprehensive Mendelian randomization (MR) framework to gut microbiota and gastric cancer GWAS summary statistics to identify 14 microbial taxa significantly associated with gastric cancer risk....

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PMID: 42202547
DOI: 10.1016/j.cancergen.2026.05.008

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